Total items: 53

Accepted/Published: 53

Under Review: –

Citations: 419 (Source: Google Scholar, Updated: 22 July 2019 )

H-index: 12

i10-index: 13


1. Nikhil Bhalla, Semiconductor Technology for Drug Discovery ISBN: 978-3-659-83905-4 First Edition: 2016

Journal Issues Edited
(Guest Editor)

1. Nikhil Bhalla (Editor) ”Shaping current and future kinase drug discovery” Current Topics in Medicinal Chemistry17 (22) 2469-2508. 2017

Editorial: Nikhil Bhalla, Shaping current and future kinase drug discovery 17-22,2469. 2017


3. Nikhil Bhalla, Amy Shen Fried, Nanoplasmonic materials and uses thereof , US Patent application No. PCT/ JP2018/028765, Year: 2018

2. Nikhil Bhalla, Amy Shen Fried, Kang-Yu Chu Nanoplasmonic Instrumentation: materials,methods and system integration, US Patent application No. WO2018JP16893 20180418 , Year: 2018

1. Nikhil Bhalla, Mirella Di Lorenzo, Giordano Pula, Pedro Estrela, Materials and Methods for Analyzing Phosphorylation of Target Protein UK Patent application No. WO2015GB51038 20150402 , Year: 2015


* corresponding author

# joint 1st author, equal contribution


25. Johanna Roether, Kang-Yu Chu, Norbert Willenbacher, Amy Q. Shen and Nikhil Bhalla*, Real-time monitoring of DNA immobilization and detection of DNA polymerase activity by a microfluidic nanoplasmonic chip Biosensors and Bioelectronics In Press

24. Nikhil Bhalla*, Afshan Jamshaid, Mandy Hei Man Leung, Noriko Ishizu and Amy Q. Shen. Electrical Contact of Metals at the Nanoscale Overcomes the Oxidative Susceptibility of Silver-Based Nanobiosensors ACS Applied Nano Materials 2(4), 2064-20752019

ACS Applied Nano Materials Front Cover


23. Nikhil Bhalla, Hung-Ju Chiang and Amy Q. Shen, ”Cell biology at the interface of microfluidics and nanobiosensors” Methods in Cell Biology 148, 203-227. 2018

22. Riccardo Funari#Nikhil Bhalla#Kang-Yu Chu, Bill Soderstorm, and Amy Q. Shen, ”Nanoplasmonics for real-time and label-free monitoring of microbial biofilm formation”ACS Sensors 3 (8), 1499–1509. 2018

21. Nikhil Bhalla*, Pedro Estrela ”Exploiting the signatures of nanoplasmon-exciton coupling on proton sensitive insulator-semiconductor devices for drug discovering applications” Nanoscale 10,133280-13328. 2018

20. Nikhil Bhalla, Shivani Sathish, Abhishek Sinha and Amy Q. Shen. ” Large scale nanophotonic structures for long term monitoring of cell proliferation.” Advanced Biosystems2(4),1700258. 2018

Advanced Biosystems Front Cover 2(4). 2018

19. Ainash Garifullina, Nikhil Bhalla*, Amy Q. Shen* ”Probing Specific Gravity in Real-time With Graphene Oxide Plasmonics ” Analytical Methods 10, 290-297. 2018

Analytical Methods Back Cover 10, 397-398. 2018

RECENT HOT ARTICLE in Analytical Methods

18. Nikhil Bhalla*, Shivani Sathish, Casey J. Galvin, Robert A. Campbell, Abhishek Sinha and Amy Q. Shen* ”Plasma assisted large-scale nanoassembly of metal-insulator bioplasmonic mushrooms” ACS Applied Materials & Interfaces 10(1),219-226. 2018


17. Parul Sharma; Adikshita, Monica Sharma, Nikhil Bhalla*, Pedro Estrela, Aditya Jain, Atul Thakur*, Preeti Thakur ”Nanomaterial Fungicides: In vitro and in vivo antimycotic activity of cobalt and nickel nanoferrites on phytopathogenic fungi” Global Challenges 1(9),1700041. 2017

Global Challenges Front Cover 1(9). 2017

16. Nikhil Bhalla*, Pedro Estrela ‘Biosensors for screening kinase inhibitors’ Current Topics in Medicinal Chemistry 17, 2470-2481. 2017

15. Nima Aliakbarinodehi, Pawan Jolly, Nikhil Bhalla, Anna Miodek, G. De Micheli, Pedro Estrela, Sandro Carrara ”Aptamer-based Field-Effect Biosensor for Tenofovir Detection”Scientific Reports (Nature) 7, 44409. 2017

14. Nikhil Bhalla, Mirella Di Lorenzo, Pedro Estrela, Giordano Pula; ”Semiconductor technology in drug discovery for protein kinase inhibitors” Drug Discovery Today 22(2) 204-209.2017

13. Nikhil Bhalla, Doojin Lee, Shivani Sathish, Amy Q. Shen ”Dual-mode refractive index and charge sensing to investigate complex surface chemistry on nanostructures”Nanoscale 9, 547-554 2017

Nanoscale Inside Front Cover 9, 468-468. 2017

12. Abhilash pathania, Preeti Thakur, Atul Thakur, Nikhil Bhalla, Patrick Queffelec, Pedro Estrela, Jean-Luc Mattei, Kush Rana, “Raman and Mӧssbauer spectroscopic studies of tungsten doped Ni-Zn Nano ferrite” Journal of Materials Science: Materials in Electronics 28(1) 679- 685. 2017


11. Vibha Tamboli #, Nikhil Bhalla #, Pawan Jolly, Chris R. Bowen, John T. Taylor, Jenna L. Bowen, Chris J. Allender, Pedro Estrela ”Hybrid Synthetic Receptors on MOSFET Devices for Detection of Prostate Specific Antigen in Human Plasma ” Analytical Chemistry 88(23), 111486-11490. 2016

10. Nikhil Bhalla, Pawan Jolly, Nello Formisano, Pedro Estrela; ” Introduction to Biosensors” Essays in Biochemistry 60 (1) 1-8. 2016

9. Nello Formisano , Nikhil Bhalla , Mel Heeran , Juana Reynes Martinez , Amrita Sarkar , Maisem Laabei , Pawan Jolly , Chris Bowen , John Taylor , Sabine Flitsch, Pedro Estrela; ”Inexpensive and fast pathogenic bacteria screening using field-effect transistors” Biosensors and Bioelectronics 85, 103-109. 2016


8. Anna Miodek, Edward MM. Regan, Nikhil Bhalla, Neal A.E. Hopkins, Sarah A. Goodchild, Pedro Estrela; ”Optimization and Characterisation of anti-fouling ternary SAM layers for impedance-based aptasensors”Sensors 15, 25015-25031. 2015

7. Nello Formisano, Pawan Jolly, Nikhil Bhalla, Mary Cromhout, Shane Flanagan, Ronen Fogel, Janice L Limson, Pedro Estrela; “Optimisation of an Electrochemical Impedance Spectroscopy aptasensor by exploiting Quartz Crystal Microbalance with Dissipation Signals” Sensors and Actuators B: Chemical 220, 369-375. 2015

6. Nikhil Bhalla, Nello Formisano, Anna Miodek, Aditya Jain, Mirella Di Lorenzo, Giordano Pula, Pedro Estrela;”Plasmonic ruler on field effect device for kinase drug discovery applications” Biosensors and Bioelectronics 71,121-128. 2015

5. Nello Formisano#, Nikhil Bhalla#, Caleb Wong#, Mirella Di Lorenzo, Giordano Pula,Pedro Estrela; ”Multimodal electrochemical and nanoplasmonic biosensors using ferrocene crowned nanoparticles for kinase drug discovery applications” Electrochemistry Communication 57,70-73. 2015

4. Nikhil Bhalla, Mirella Di Lorenzo, Giordano Pula, Pedro Estrela;”Protein phosphorylation detection using dual-mode field-effect devices and nanoplasmonic sensors” Scientific Reports (Nature) 5, 8687. 2015


3. Jules L Hammond#, Nikhil Bhalla#, Sarah D. Rafiee#, Pedro Estrela; ” Localized Surface Plasmon Resonance as a Biosensing Platform for Developing Countries” Biosensors 4, no. 2: 172-188. 2014

2. Nikhil Bhalla, Mirella Di Lorenzo, Giordano Pula, Pedro Estrela; ”Protein phosphorylation analysis based on proton release detection: potential tools for drug discovery‘ Biosensors and Bioelectronics ,54, 109-114. 2014


1. Nikhil Bhalla; Chung, Danny W.Y.; Chang, Yaw-Jen; Uy, Kimberly J.S.; Ye, Yi Y.; Chin, Ting-Yu; Yang, Hao C.; Pijanowska, Dorota G. “Microfluidic Platform for Enzyme-Linked and Magnetic Particle-Based Immunoassay.” Micromachines 4, no. 2: 257-271. 2013

International Conference Proceedings (Peer-Reviewed/SCI /EI indexed)

11. Riccardo Funari, Nikhil Bhalla, Kang-Yu Chu and Amy Q. Shen, Monitoring Bacterial Biofilm Formation using LSPR Sensors for Biofilm Drug Screeing 7th International Symposuim on Sensor Science , Napoli, Italy, May 2019 (poster)


10. Nikhil Bhalla, Riccardo Funari and Amy Q. Shen, Nanoplasmonic platform for multiple biosensing applicationsMicroTAS , Kaohsiung, Taiwan, November 2018 (oral)


9. Nikhil Bhalla, Shivani Sathish, Amy Q. Shen, Novel refractive index biosensing of microcontact printed molecules on lithium niobate, 38th Annual International conference of the IEEE Engineering in Medicine and Biology Society (IEEE-EMBC), Orlando,USA, August 2016 (oral/ poster)


8. Nikhil Bhalla, Wen Yaw Danny Chung, Kerwin Wang, Teddy Lessmana, Pedro Estrela, Electrowetting enabled magnetic particle immunoassay with on-chip magnetic washingProceedings of IEEE-SENSORS , Baltimore, USA, Novemeber 2013 (poster)


7. Teddy Lesmana, Wen-Yaw Chung, Nguyen-Tan Nhut Quang, Nikhil Bhalla, A Linear Current to Frequency Converter for Amperometric Glucose Sensing System, BMES International Symposium of Biomedical Engineering, Taoyuan, Taiwan, November 2012 (oral)

6. Danny Wen Yaw Chung, Nikhil Bhalla, Hsi-Wen Li, Yi Ying Ye, Hao Chun Yang, Dorota G. Pijanowska Hall’s Effect Based Sensing Mechanism for Nano Super Paramagnetic Particle-Protein Complex Structure, IEEE Asia Pacific Conference on Transducers APCOT, Nanjing, China, July 2012 (poster)

5. Nikhil Bhalla, Danny Wen Yaw Chung, Kimberly Jane S. Uy, Dorota G. Pijanowska Nitrocellulose based Microfluidic Platform for Immunoassay, IEEE-Asia Pacific Conference on Transducers APCOT, Nanjing, China, July 2012 (poster)


4. Nikhil Bhalla, Sheng Shian LiDanny Wen-Yaw Chung Finite Element Analysis of MEMS Based Piezoresistive Accelerometer Designs with Low Crosstalk. IEEE-International Conference on Semiconductor CAS, Sinaia, Romania, October 2011 (oral)

3. Nikhil Bhalla, Sheng Shian LiDanny Wen-Yaw Chung Multi- Domain analysis of MEMS Based Si structures, COMSOL-International Conference , Boston ,USA, October 2011(poster)

2. Nikhil Bhalla, Sheng Shian LiDanny Wen-Yaw Chung Simulations of MEMS based Piezoresistive Accelerometer Design in COMSOL, COMSOL-International Conference , Boston, USA, October 2011 (oral)


1. Nikhil Bhalla, Danny Wen-Yaw Chung, Sundaram Sumaninathan Optical Detection of Cancer and Development of Feedback Assisted Surgical Scalpel, BMES International Symposium of Biomedical Engineering, Kaohsiung, Taiwan, December 2010. Awarded for one of best papers in the symposium) (poster)

International Conference Abstracts (Peer-Reviewed)

12. N. Bhalla, S. Sathish, A. Q. Shen ‘Metal-insulator nanomushrooms for ultrasensitive bioassays using microcontact printing of proteins’ World Congress on Biosensors 2018, Miami, USA, June 2018 (oral)

11. N. Bhalla, S. Sathish, A. Sinha, A. Q. Shen ‘Biocompatible large scale nanoplasmonic structures for long term monitoring of cell mitosis’ World Congress on Biosensors 2018, Miami, USA, June 2018 (poster)

10. R. Funari N. Bhalla, K.Y. Chu, A. Q. Shen ‘Nanoplasmonics for long term and label free continuous monitoring of bacteria biofilm formation’ World Congress on Biosensors 2018, Miami, USA, June 2018 (oral)

9. A. Garifullina, N. Bhalla, A. Q. Shen ‘Probing specific gravity in real time using graphene oxide plasmonics’ World Congress on Biosensors 2018, Miami, USA, June 2018 (poster)


8. N. Bhalla, S. Sathish, A. Q. Shen ‘Dual mode mass-charge nanoplasmonic field-effect biosensors’ 5th International Conference on Bio-Sensing Technology, Riva del Garda, Italy, May 2017 (oral)


7. V.K. Tamboli, N Bhalla, P. Jolly, J.L. Bowen, C.J. Allender, P.Estrela ‘BioFET for detection of PSA using synthetic hybrid receptors’ The 9th international Conference on Molecular Imprinting (MIPS 2016) , Lund, Sweden, June 2016 (oral)

6. N. Formisano, N Bhalla, M. Heeran, J.Reyes Martinez, M.Laabei, P.Jolly, C.R. Bowen, J.T. Taylor, P.Estrela ‘Inexpensive and fast pathogenic bacteria screening using field-effect transistors’, World Congress on Biosensors 2016Gothenburg , Sweedon, May 2016 (poster)


5. N Bhalla, S Pathak, CR Bowen, JT Taylor, M Di Lorenzo, G Pula, P Estrela ‘ Field-effect devices for kinase drug discovery’ 4th International Conference on Bio-Sensing Technologies, Lisbon, Portugal, May 2015 (poster)

4. Nello Formisano, Nikhil Bhalla, Caleb Wong, Pedro Estrela’ Multi-mode electrochemical biosensing for kinase drug discovery applications using ferrocene crowned nanoparticles’ 4th International Conference on Bio-Sensing Technologies, Lisbon, Portugal, May 2015 (poster)

3. N Bhalla, N Formisano, A Miodek, M Di Lorenzo, G Pula, P Estrela ‘Integrated nanoplasmonic and field-effect devices for kinase drug discovery‘ 2nd International Conference on Label-Free Technologies, Boston, USA,March 2015 (oral ‘keynote talk’)


2. P Jolly, N Formisano, SD Rafiee, N Bhalla, A Miodek, R Dondi, DK Yang, LC Chen, P Kasak, J Tkac, MD Lloyd, I Eggleston, P Estrela, DNA aptamer-based approaches for detection of multiple prostate cancer biomarker 22nd Meeting of the EAU Section of Urological Research ESUR 2014, Glasgow,UK, October 2014 (poster)

1. Nikhil Bhalla, Mirella Di Lorenzo, Giordano Pula, Pedro Estrela, Novel tools for protein phosphorylation analysis based on proton release detection, World Congress on Biosensors 2014Melbourne, Australia, May 2014 (oral)


Note: Other scientific published/presented articles at National symposiums available on request. email: [email protected]

PhD thesis:

Nikhil Bhalla: Biosensors for drug discovery applications

Masters thesis:

Nikhil Bhalla: Microfluidic platform for immunoassay